Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia
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منابع مشابه
Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia.
The highly reactive pulmonary vascular bed of the neonatal calf was utilized to determine whether the hypoxic pulmonary pressor response is modified by alpha-adrenergic blockade with phenoxybenzamine (Group A) or by tissue catecholamine depletion with reserpine (Group B). In addition, in Group A, the effects of hypoxia on the pulmonary circulation were compared and contrasted with those of l-no...
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128 COMMUNICATIONS TO THE EDITOR CHEST, 81: 1, JANUARY, 1982 were normal and the blood pressure was 120/70 mm Hg. The apex beat was dyskinetic and he had an apical 4th heart sound. The ECC showed anterior myocardial infarction. He had a graded exercise test using the Bruce protocol; he ran for eight minutes and reached his target heart rate (180 beats/minute) without chest pain or ST segment ch...
متن کاملEffects of Alpha Adrenergic Blockade
This work was presented in part at the 26th Annual Scientific Session of the American College of Cardiology in Las Vegas, Nevada, 7-10 March 1977. Dr. Ricci was supported by a grant from the Canadian Heart Association. Received for publication 18 July 1977 and in revised form 17 March 1978. INTRODUCTION In the normal heart, coronary blood flow is matched to myocardial metabolic work requirement...
متن کاملRegulation of myocardial and vascular alpha-adrenergic receptor affinity. Effects of guanine nucleotides, cations, estrogen, and catecholamine depletion.
The threshold sensitivity of cardiovascular tissues to alpha-adrenergic stimulation is determined largely by the affinity of alpha-adrenergic receptors for agonists. To determine whether changes in alpha-adrenergic receptor affinity could contribute to the regulation of cardiac and vascular responsiveness, we used the alpha-adrenergic-selective radioligands, [3H]prazosin, [3H]-WB-4101, and [3H]...
متن کاملThe Role of Anion Exchanger on Pulmonary Vascular Response to Sustained Alveolar Hypoxia in the Isolated Perfused Rabbit Lung
Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1968
ISSN: 0021-9738
DOI: 10.1172/jci105724